MLB: Chicago White Sox vs Cleveland Guardians odds, picks, and predictions

At Progressive Field on Wednesday, the Chicago White Sox (6-3) face the Cleveland Guardians (4-5) in the first game of a typical doubleheader. Rain canceled the White Sox-Guardians games on Monday and Tuesday, forcing a doubleheader on Wednesday. The Cubs won their first three series, all 2-1, against the Detroit Tigers on Opening Day and then at home last week against the Seattle Mariners and Tampa Bay Rays.

Cleveland entered the last series with San Francisco on a four-game winning streak, but the Giants swept them at home last weekend, outscoring them 16-4. The White Sox defeated the Guardians 10-9 in last season's regular-season series, and Chicago outscored Cleveland 81-74.

Chicago White Sox vs Cleveland Guardians: Projected starters

RHP Shane Bieber vs. LHP Dallas Keuchel

Keuchel (1-0, 5.40 ERA) beat the Mariners 12-11 in his first start last Wednesday, pitching 5 1/3 innings with five earned runs on five hits and one walk while striking out four batters. Bieber (0-0) has a pair of no-decisions on the road this season, against the Kansas City Royals and Cincinnati Reds. In Cleveland's 10-5 win over the Reds on April 12, he pitched 5 1/3 innings with three earned runs on two hits and three walks while striking out five batters.

Chicago White Sox vs Cleveland Guardians picks and predictions

Prediction: Guardians 6, White Sox 3