MLB: San Diego Padres vs Cincinnati Reds odds, picks, and predictions

The San Diego Padres (11-7) take on the Cincinnati Reds (3-14) in the second game of their three-game series at Great American Ballpark on Wednesday. The game will begin at 6:40 p.m. ET. San Diego won the series opener 9-6 thanks to an 8-run fourth-inning rally highlighted by a 3-run home run by Padres 1B Eric Hosmer. Padres lead the season series 4-0 and have outscored the Reds by 16 runs.

San Diego Padres vs Cincinnati Reds projected starters

RHP Vladimir Gutiérrez vs. LHP MacKenzie Gore

In his last start, Gore (1-0, 1.74 ERA) defeated Cincinnati 6-0. He threw 5 scoreless innings with 4 hits, 2 walks, and 7 strikeouts. Gutiérrez (0-3, 5.54 ERA) took the loss in that April 20 game against San Diego, pitching 4 2/3 innings and allowing three runs on two hits and four walks while striking out two batters.

San Diego Padres vs Cincinnati Reds picks and predictions

Prediction: Padres 7, Reds 3