MLB: Chicago White Sox vs Cleveland Guardians odds, picks, and predictions

The Chicago White Sox (6-3) take on the Cleveland Guardians (4-5) in the first of a three-game series on Tuesday. The first pitch is slated for 6:10 p.m. ET (ESPN+) from Progressive Field in Cleveland. Let's look at the White Sox vs. Guardians odds and make some MLB predictions. The White Sox won the series 10-9 in 2021. The clubs were supposed to start a four-game series on Monday, but a cold rain/snow combination canceled the first game, which was rescheduled for July 12. Last season, the White Sox won five of the nine encounters in Cleveland.

The Guardians won four of their first six games this season — all on the road — but were swept in a three-game interleague series against the San Francisco Giants over the weekend, so they're still looking for their first home win of 2022.

Cleveland Guardians vs. Chicago White Sox Starters expected

RHP Shane Bieber vs. LHP Dallas Keuchel

Keuchel (1-0, 5.40 ERA) will make his second start of the season. In his debut start against the Seattle Mariners on Wednesday, he gave three earned runs on six hits and zero walks while striking out five batters in five innings. Last Tuesday, Bieber (0-0, 2.70 ERA) pitched 5 1/3 innings against the Cincinnati Reds, allowing three runs on two hits and three walks while striking out five batters. This will be his first appearance at home in 2022.

Chicago White Sox vs Cleveland Guardians picks and predictions

Prediction

Guardians 4, White Sox 2